Influence of Lipoteichoic acid D-alanylation on protein secretion in Lactococcus lactis as revealed by random mutagenesis
Article Abstract:
Lactococcus lactis, is a food-grade nonpathogenic lactic acid bacterium, widely used in the food industry and is considered a good candidate for the production of heterologous proteins of therapeutic interest. An insertional mutagenesis analysis is presented, in which accessory genes involved in the production and secretion of heterologous proteins in L. lactis are identified.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2004
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Constitutive delivery of bovine [beta]-lactoglobulin to the digestive tracts of gnotobiotic mice by engineered Lactobacillus casei
Article Abstract:
A recombinant Lactobacillus casei strain is constructed that can constitutively deliver bovine [beta]-lactoglobulin (BLG), a major cow's milk allergen, to the guts of gnotobiotic mice. The analysis of this strain has indicated that gut colonization with allergen-producing lactobacilli can help in studying the modulation of allergic disorders.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2006
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